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                    Life & Chemical Sciences Seminars

Electrochemistry meets Medicinal Chemistry: Successful
Examples
Marilia O. F. Goulart, Prof.
Instituto de Química e Biotecnologia, UFAL, Maceió, Alagoas, Brazil

Venerdì 7 Settembre, ore 14:30 – Aula 2, via Belmeloro 6
(Prof.ssa Maria Laura Bolognesi)
Abstract
There is a beneficial interface between electrochemistry and life sciences, useful for the design,
development and characterization of redox-selective molecules and their molecular mechanism of action
[1,2]. The ever-increasing interest in biologically active quinones has resulted in new strategies to
decrease toxicity, modulate activity, and direct the compound to the target. As such, it is pertinent to
continue to explore their synthesis, biological activities and redox mechanisms through a combined
theoretical and experimental approach.
In the present case, several successful examples of the use of electrochemical techniques in medicinal
chemistry is shown, concerning multiple redox-centered hybrid quinones, like pterocarpanequinones [3],
chalcogenated [4], halogenated, and fluorescent ones [5], using cyclic voltammetry,
spectroelectrochemistry, computational chemistry [6] and electrochemical-based macromolecular
interaction studies [7] (Figure 1). Electrochemical studies play, indeed, a beneficial role in biomedicine
and as perspectives, more adequate cell models and interaction among areas of research are urgently
required. It is time to rationalize the synthesis of quinones and better work the question of selectivity,
activity modulation, in situ drug delivery, among other strategies, to have a more realistic and applied
action.

Figure 1. Examples of electrochemical-based medicinal studies
Acknowledgements to CAPES, CNPq, FAPEAL, RENORBIO, INCT-Bioanalítica
References: [1] Hillard E.A. et al., Chem. Commun. 2008, 2612-2628; [2] Paiva, Y.G. et al., Curr. Top. Med.
Chem. 2015, 15, 136-162. [3] Silva, T. L. et al. ChemElectroChem. 2016, 3, 1-13. [4] Jardim et al. 2015. RSC
Advances 5, 78047-78060. [5] Gontijo et al. Chem. Commun 2016, 52, 13281–13284. [6] ArmendárizVidales et
al., J. Org. Chem. 2014, 79, 5201-5208, [7] De Vasconcellos et al.,J. Electroanal. Chem. 2016, 765, 168-178.

Biosketch
Full Professor: Instituto de Química e Biotecnologia - Universidade Federal de
Alagoas (UFAL), Cidade Universitária, Tabuleiro do Martins, Maceió, Alagoas,
Brasil 57.072-970. Chemistry and Biotechnology Institute, Federal University
of Alagoas, Tabuleiro dos Martins, Maceio, Alagoas, Brazil, 57072-970.
Tel: 55-82-32141393; Fax: 55-82-32141389.
ORCID Number: 0000-0001-9860-3667.
Research ID: A-1199-2013
Full Member of the Brazilian Academy of Sciences
mariliaofg@gmail.com; mofg@qui.ufal.br
H index: 34 (Scopus) >3500 citations; 33 (ISI)
EDUCATION: Pharmacist (1975) Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Belo
Horizonte, MG, Brazil, PhD (13/10/1983): Chemistry Department, Federal University of Minas Gerais, Brazil, under
the supervision of Alaíde Braga de Oliveira. Post doctoral 09/1985 – 08/1987: Queen Mary and Westfield College,
University of London, with Prof. James Utley. Synthesis and Electrochemistry of quinonemethides and their
behavior as pro-bases; 04/1992 –10/1992: Organisch-Chemisches Institüt, Münster, Germany, with Prof. Hans-J.
Schäffer. Diastereoselective Kolbe reactions. Visiting professor 10/2004 – 04/2005; 03/2007-04/2007; 09/2008:
Ecole Normale Supérieure. Département de Chimie. UMR CNRS 8640 PASTEUR, with Prof. Christian Amatore.
RESEARCH ACTIVITIES
Organic Electrochemistry: investigation of the reduction/oxidation mechanisms of natural products, organic
halides, compounds of mixed functionality and several other classes of biologically active compounds (quinones,
N-oxides, NO donors, phenols, nitroaromatics, etc), and correlation of thermodynamic and kinetic parameters
(Eredox and others) with biological activities, helping in the investigation of molecular mechanism of action. Organic
electrosynthesis: electrochemical modification of natural products by reduction and oxidation.
Bioelectrochemistry/ Electroanalysis: DNA biosensors, chemical sensors for quantification and analysis of
compounds of biomedical importance. Electron transfer/Oxidative Stress studies: clinical and animal models
investigation on diseases based on oxidative stress, quantification of biomarkers of oxidative stress and their
relationship with diseases (cardiovascular, diabetes, gastrointestinal ones, metabolic syndrome), amperometric
monitoring of oxidative bursts at single cells level, in the presence of quinones. Boron dopped diamond electrodes.
Food Chemistry: determination of antioxidant and pro-oxidant activities of nutraceuticals and residues from the
food industry, development of new methodologies. Carbonylic Stress.
PUBLICATIONS/SUMMARY
Publications: 166; Patents: 4; Book Chapters: 12
Master Science under my supervision: 29 + 4 in co-supervision; under way: 04
PhD under my supervision: 30 + 5 in co-supervision); under way: 10
Post-doctoral supervision: 08; under way: 02
Awards: 12
AWARDS & HONORS:

1984. “YOUNG SCIENTIST AWARD” – National Brazilian Award. First place. Category: graduate - CNPq,
Fundação Roberto Marinho, Grupo Ultra.

1997. “FOREIGN YOUNG CHEMIST AWARD” - International Symposium-Electroorganic Synthesis’97,
Kurashiki, Japan - IS-EOS’97, September 1997.

2011. National Award Marie Curie. Distinguished Women on Chemistry. Sociedade Brasileira de Química
(Brazilian Society of Chemistry)

2012. Jabuti Award “Química Medicinal: Novas Estratégias em Planejamento Racional de
Fármacos, 2010, p. 186-229. EDUSP. ISBN: 9788531412660

2013. XIX SIBEE Honoured Professor (Simpósio Brasileira de Eletroquímica e Eletroanalítica, Brazilian
Symposium on Electrochemistry and Electroanalysis)

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